Prevention of Preterm Labour: 2011 Update on Tocolysis
نویسندگان
چکیده
The aim of this paper is to review available data about drugs for preventing preterm labour. Tocolytic therapy includes β adrenergic receptor agonists, NO donors, magnesium sulphate, prostaglandin-synthase inhibitors, oxytocin receptor antagonists, calcium-channel blockers, progesterone, 17-α-hydroxyprogesterone caproate, and antibiotics. Their specific effects on myometrial contractility, their safety, their efficiency, and side effects profile for the mother and the fetus are presented. The main question of why and for what reasons tocolysis should be administrated is discussed.
منابع مشابه
Clinical Medicine Insights: Women’s Health
The purpose of this review was to look at the evidence available for the use of atosiban as a tocolytic in cases of threatened preterm labour. A Royal College of Obstetricians and Gynaecologists Green Top Guideline concluded that there was no clear evidence to show a benefit to tocolysis in reducing perinatal and neonatal morbidity and mortality. Using a systematic literature search, we summari...
متن کاملTocolytic Drugs for Women in Preterm Labour
Preterm birth is the most important single determinant of adverse infant outcome, in terms of both survival and quality of life. Although preterm birth is defined as being before 37 completed weeks, most mortality and morbidity is experienced by babies born before 34 weeks. Prevention and treatment of preterm labour is important, not as an end in itself, but as a means of reducing adverse event...
متن کاملRole of the prostaglandins in labour and prostaglandin receptor inhibitors in the prevention of preterm labour.
Parturition is composed of five separate but integrated physiological events: fetal membrane rupture, cervical dilatation, myometrial contractility, placental separation, and uterine involution. Prostaglandins (PGs) have central roles in each of these events, but the most studied is myometrial contraction. Elevated uterine PGs or the enhanced sensitivity of the myometrium to PGs leads to contra...
متن کاملIndividual and Organisational Determinants Associated with Maintenance Tocolysis in the Management of Preterm Labour: A Multilevel Analysis
BACKGROUND Clinical guidelines do not recommend maintenance tocolysis for the management of preterm labour. The French national survey EVAPRIMA revealed it was administered to more than 50% of women hospitalised for preterm labour. Our aim was to identify the individual and organisational determinants associated with maintenance tocolysis. METHODS The study was a secondary analysis of the pro...
متن کاملContractility of the myometrium; the rationale for pharmacological intervention in preterm labour.
Thank you for asking us to comment on the issues raised by Professors Åkerlund and Mars̆ál. We would like to thank them for their interest and comments. We agree that in some cases of preterm labour, tocolysis is contraindicated. In particular, if there is significant fetal distress it would be unwise to delay delivery. Since preterm labour is multifactorial, there are a range of precipitating c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011